Chicago Med cliffhanger preview: What’s next for Manstead?

"With A Brave Heart" Episode 422 -- Pictured: Torrey DeVitto as Dr. Natalie Manning -- (Photo by: Elizabeth Sisson/NBC)
"With A Brave Heart" Episode 422 -- Pictured: Torrey DeVitto as Dr. Natalie Manning -- (Photo by: Elizabeth Sisson/NBC) /

What will happen next on Chicago Med? Look back at the Chicago Med cliffhanger and ahead to possible resolutions in the Chicago Med season 5 premiere.

Every One Chicago series ended on a cliffhanger last season, including Chicago Med, which left the audience wondering if Dr. Natalie Manning (Torrey DeVitto) survives after a nasty car wreck, and what the accident means for Manstead.

As we continue to count down the time to the show’s Sept. 25 return, we’re looking at each of the cliffhangers again—refreshing fans’ memory, sharing possible clues and newly emerged spoilers, and then making our final predictions as to what will happen.

SPOILER ALERT: This article contains speculation about this season’s upcoming premiere, and may include spoilers/potential spoilers from information that is currently available.

Take a look back at the final moments of Chicago Med season 4, before we try and figure out how the storyline will be wrapped up in the Chicago Med season 5 premiere.

The cliffhanger

If you want to refresh your memory, play the video below to see the Chicago Med cliffhanger from the end of last season:

What we’ve learned since

The Chicago Med producers have given away what happens to Natalie already: she lives, but will suffer a traumatic brain injury in the accident. We might still get a proposal, too, since her current squeeze Phillip Davis (recurring guest star Ian Harding) is sticking around.

As for the other two cliffhangers, April Sexton’s (Yaya DaCosta) possible pregnancy and Maggie Lockwood’s (Marlyne Barrett) cancer? No concrete details yet regarding either one.

Watch One Chicago on fuboTV: Watch over 67 live sports and entertainment channels with a 7-day FREE trial!

So what happens next?

Expect the premiere to be about treating Natalie’s injuries, getting the TBI diagnosis, and a lot of angsting by/glaring between her ex-fiance Dr. Will Halstead (Nick Gehlfuss) and Phillip. They’ll disagree over what’s best for Natalie, because they haven’t agreed on anything yet.

One Chicago fans know Natalie can’t spend the whole season in a hospital bed, so either there will be a time jump—similar to how one was employed after Dr. Daniel Charles was shot, to skip ahead to him being just fine—or perhaps the injury will turn out to be not quite as serious as it first looked. Either way, expect her to be up and back in the ED within a relatively short period, though that doesn’t mean she’ll be 100 percent.

Regarding April and Maggie, we expect one of those stories will be true and the other will be false, because the writers won’t want all of their cliffhangers to resolve the same way. It’s more likely that Maggie has cancer, because Chicago Med doesn’t need another baby. Choi’s nephew was all kinds of problematic last season, and as for Owen…will the writers do something with him now that his mom’s hospitalized?

Next. First look at Chicago Fire season 8 premiere. dark

For the latest Chicago Med season 5 spoilers and news, plus more on the entire series, follow the Chicago Med category at One Chicago Center.