Jesse Spencer and the most shocking exits from Chicago Fire, Med in 2021

"Two Hundred" Episode 1005 -- Pictured: Jesse Spencer as Matthew Casey -- (Photo by: Lori Allen/NBC)
"Two Hundred" Episode 1005 -- Pictured: Jesse Spencer as Matthew Casey -- (Photo by: Lori Allen/NBC) /
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Chicago Fire
“Blow This Up Somehow” Episode 906 — Pictured: Adriyan Rae as Gianna Mackey — (Photo by: Adrian S. Burrows Sr./NBC) /

If there is one thing that One Chicago fans have gotten used to over the years, it’s knowing that at any time one of their favorite characters could leave unexpectedly.

Over the course of the last several seasons, we’ve seen many beloved characters from Chicago Fire, Chicago Med and Chicago PD leave town — sometimes on good terms which left the door open for their returns and others in more permanent farewells courtesy of the One Chicago grim reaper.

While cast departures are nothing new, we have to say we weren’t quite prepared for the major cast shakeups that would come in 2021 which resulted in the departures of several fan-favorite characters who have long played critical roles on their respective shows.

From Jesse Spencer’s shocking exit in the 200th episode of Chicago Fire to Chicago Med‘s surprising hiatus exits, we’re taking a look back at 2021’s most shocking One Chicago cast exits and reflecting upon the characters and actors we miss most!

Adriyan Rae leaves Chicago Fire

From the moment we first met Mackey in the season 9 premiere of Chicago Fire, we had high hopes for 51’s newest paramedic and she quickly won us over. Unfortunately, Mackey left town before we could fully appreciate the character due to the departure of Adriyan Rae from the cast.

Thankfully, Mackey is still alive in the One Chicago universe, so the door remains open for a possible return down the line which is something we’re truly grateful for!