FBI: Most Wanted has come to the end of the line. Sure, the series will remain on the air until May 20, but the last day of April marked the last day of production for the popular FBI spinoff, and the actors were quick to commemorate the occasion via social media. Their posts ranged from celebratory and bittersweet to appreciative of the friends they made during the show's six years on CBS.
Shantel VanSanten commented on an FBI production account and noted that she's grateful for the experience of making Most Wanted. "Today marks the end of an era for an epic adventure as we film the last episode EVER of Most Wanted," she wrote. "I am so grateful to be here for this moment and celebrate a cast/crew that has brought you 100+ episodes of great TV!!" VanSanten also mentioned that she was "lucky" to have played Nina Chase for three seasons.
Keisha Castle-Hughes "treasures" FBI memories

Keisha Castle-Hughes and Edwin Hodges had less to say about their time on the show, despite having been around for six seasons and three seasons, respectively. Both actors did, however, note that April 30, 2025 marked the end of an era for them. "Closing out six years," Castle-Hughes dutifully captioned.
This is not the first time the actress has made her opinion on the FBI: Most Wanted cancelation known. She was actually one of the first people to issue a statement upon CBS' surprising decision. "Thanks to Wolf Films and to CBS, David Hudgins and Ken Girotti for supporting an incredible run of the show," Castle-Hughes told Us. "I will treasure the memories and friendships built over my time on the series and the years spent."
Roxy Sternberg praised FBI's cast and crew

Roxy Sternberg, who plays Sheryll Barnes, went a more celebratory route. She made it clear that she show could not have reached the level of success it did were it not for the people who worked on the show behind the scenes, and the fans who tuned in every week to see what happened. "6 years later, it’s a wrap," she confirmed. "Thank you to the best cast and crew."
It's always sad to see a long-running show get the boot, but the silver lining, of course, is that the FBI franchise lives on, and characters who will no longer be seen on a weekly basis through Most Wanted may still get a chance to appear and make cameos on the flagship series (or other spinoffs). It's not the best condolence prize, but it's something.