Sophia Bush makes her debut in Grey's Anatomy season 21, episode 6 (Preview)

There are a lot of relationship issues coming up in Grey’s Anatomy season 21, episode 6. Could one relationship come to an end?

When we heard that Sophia Bush would guest star in Grey’s Anatomy season 21, we were excited. However, it does look a little like Bush’s character is going to have a similar storyline to one of her One Tree Hill co-star storylines from a few years back.

Think back to season 9 when Dr. Lauren Boswell came into the story. Hilarie Burton’s character led to the demise of Calzona after Boswell made it clear that she didn’t care that Arizona was married. She was going to encourage an affair and then just walk away. Could we see that happen with Bush’s character?

Trouble in love in Grey’s Anatomy season 21, episode 6

The promo for the new episode certainly hints at that. Bush’s character talks to Teddy at the bar of the restaurant she and Owen are at. Bush’s character shares that when she and her husband had trouble in their marriage, they opened the marriage up. In other words, the two sleep with other people to make sure they’re happy together.

Is this a way for Bush’s character to get in between Teddy and Owen? We know that Teddy has cheated before, and Owen had an affair when he was married to Cristina. It’s not like either of them are innocent!

Meanwhile, at the hospital, Lucas and Simone see a bit of trouble in love. As Lucas leaves, Simone says “love you.” It’s clear that Lucas wasn’t expecting to hear that and he doesn’t respond. I still have doubts about Simone’s feelings for Lucas. Could this be the end of their budding relationship?

We do get to see Mika back, though, which offers hope that there’s something for her and Jules. While it probably won’t mean them getting back together, just seeing their friendship will be enough for now as Mika’s exit storyline is brought to us.

Check out the promo and synopsis for Grey’s Anatomy season 21, episode 6:

"Teddy and Owen plan a date night that gets derailed in more ways than one, while Jo struggles to do it all at home. Mika adds more to her plate to make up for taking time off to be with her sister, and Levi is faced with a monumental decision."

Images for Grey’s Anatomy season 21, episode 6

Interestingly, there are no promo images of Sophia Bush just yet. Hopefully, we’ll get some soon as she’s supposed to be a recurring guest character.

There are some images of Mika and Jules together. It looks like Jules will continue to be a friend, but is that in the hope that there will be something more between them? There’s also a look at Levi’s storyline, who gets to be Bailey’s attending for the night. Is this going to give him a look at where he could work best in medicine?

Grey’s Anatomy airs Thursdays at 10/9c on ABC. Catch up the following day on Hulu.